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Ingredients & Clinical Trial Citations

  • Pratte, M. A., Nanavati, K. B., Young, V., & Morley, C. P. (2014). An Alternative Treatment for Anxiety: A Systematic Review of Human Trial Results Reported for the Ayurvedic Herb Ashwagandha (Withania somnifera). Journal of Alternative and Complementary Medicine20(12), 901–908. http://doi.org/10.1089/acm.2014.0177

Bacopa (Brahmi)

  • Kongkeaw C, Dilokthornsakul P, Thanarangsarit P, Limpeanchob N, Norman Scholfield C. Meta-analysis of randomized controlled trials on cognitive effects of Bacopa monnieri extract. J Ethnopharmacol. 2014;151(1):528-35. doi: 10.1016/j.jep.2013.11.008. Epub 2013 Nov 16. Review. PubMed PMID: 24252493.


  • Srivastava, J. K., Shankar, E., & Gupta, S. (2010). Chamomile: A herbal medicine of the past with bright future. Molecular Medicine Reports3(6), 895–901. http://doi.org/10.3892/mmr.2010.377


    • Liu, L., Liu, C., Wang, Y., Wang, P., Li, Y., & Li, B. (2015). Herbal Medicine for Anxiety, Depression and Insomnia. Current Neuropharmacology13(4), 481–493. http://doi.org/10.2174/1570159X1304150831122734

    Lemon Balm

    • Scholey, A., Gibbs, A., Neale, C., Perry, N., Ossoukhova, A., Bilog, V., … Buchwald-Werner, S. (2014). Anti-Stress Effects of Lemon Balm-Containing Foods. Nutrients6(11), 4805–4821. http://doi.org/10.3390/nu6114805 


    • Nobre AC, Rao A, Owen GN. L-theanine, a natural constituent in tea, and its effect on mental state. Asia Pac J Clin Nutr. 2008;17 Suppl 1:167-8. PubMed PMID: 18296328.


    • Talbott, S. M., Talbott, J. A., & Pugh, M. (2013). Effect of Magnolia on cortisol and psychological mood state in moderately stressed subjects. Journal of the International Society of Sports Nutrition10, 37. http://doi.org/10.1186/1550-2783-10-37


    • Sánchez-Barceló EJ, Mediavilla MD, Tan DX, Reiter RJ. Clinical uses of melatonin: evaluation of human trials. Curr Med Chem. 2010;17(19):2070-95. Review. PubMed PMID: 20423309.

    Mucuna Pruriends 14% HPLC

    • Shukla, K. K., Mahdi, A. A., Ahmad, M. K., Jaiswar, S. P., Shankwar, S. N., & Tiwari, S. C. (2010). Mucuna pruriens Reduces Stress and Improves the Quality of Semen in Infertile Men. Evidence-Based Complementary and Alternative Medicine : eCAM7(1), 137–144. http://doi.org/10.1093/ecam/nem171


    • Akhondzadeh S, Naghavi HR, Vazirian M, Shayeganpour A, Rashidi H, Khani M. Passionflower in the treatment of generalized anxiety: a pilot double-blind randomized controlled trial with oxazepam. J Clin Pharm Ther. 2001 Oct;26(5):363-7. PubMed PMID: 11679026.


    • Brock C, Whitehouse J, Tewfik I, Towell T. American Skullcap (Scutellaria lateriflora): a randomised, double-blind placebo-controlled crossover study of its effects on mood in healthy volunteers. Phytother Res. 2014 May28 (5):692-8. doi: 10.1002/ptr.5044. Epub 2013 Jul 22. PubMed PMID: 23878109.

    St. John's wort

    • Apaydin, E. A., Maher, A. R., Shanman, R., Booth, M. S., Miles, J. N. V., Sorbero, M. E., & Hempel, S. (2016). A systematic review of St. John’s wort formajor depressive disorder. Systematic Reviews5(1), 148. http://doi.org/10.1186/s13643-016-0325-2
    Plant Oils
    • Lin, T.-K., Zhong, L., & Santiago, J. L. (2018). Anti-Inflammatory and Skin Barrier Repair Effects of Topical Application of Some Plant Oils. International Journal of Molecular Sciences19(1), 70. http://doi.org/10.3390/ijms1901007


    • Guillou S, Ghabri S, Jannot C, Gaillard E, Lamour I, Boisnic S. The moisturizing effect of a wheat extract food supplement on women's skin: a randomized, double-blind placebo-controlled trial. Int J Cosmet Sci. 2011 Apr;33(2):138-43. doi: 10.1111/j.1468-2494.2010.00600.x. PubMed PMID: 20646083.

    Psyllium Powder

    • McRorie, J. W. (2015). Evidence-Based Approach to Fiber Supplements and Clinically Meaningful Health Benefits, Part 2: What to Look for and How to Recommend an Effective Fiber Therapy. Nutrition Today50(2), 90–97. http://doi.org/10.1097/NT.0000000000000089
    • Darbinyan, V & Aslanyan, Gayane & Amroyan, E & Gabrielyan, E & Malmström, C & Panossian, Alexander. (2007). Clinical trial of Rhodiola in the treatment of mild to moderate depression. Nordic journal of psychiatry. 61. 343-8. 10.1080/08039480701643290. 


    • Bent, S., Padula, A., Moore, D., Patterson, M., & Mehling, W. (2006). Valerian for Sleep: A Systematic Review and Meta-Analysis. The American Journal of Medicine119(12), 1005–1012. http://doi.org/10.1016/j.amjmed.2006.02.026
    • Wheatley D. Kava and valerian in the treatment of stress-induced insomnia. Phytother Res. 2001 Sep;15(6):549-51. PubMed PMID: 11536390.

      Consumer information from the National Institutes of Health, Office of Dietary Supplements:

      *These products have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

      **Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own physician or other medical professionals. The results reported may not necessarily occur in all individuals.


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